An integrated machine learning model of transcriptomic genes in multi-center chronic obstructive pulmonary disease reveals the causal role of TIMP4 in airway epithelial cell
We developed a 13-gene model for distinguishing COPD at the molecular level and identified TIMP4 as a potential hub pathogenic gene. This finding provides insights into shared disease mechanisms and positions TIMP4 as a promising therapeutic target for further investigation.
Authors
- Yumin Zhou (ORCID: https://orcid.org/0000-0002-0555-8391)
- Chengshu Xie (ORCID: https://orcid.org/0000-0002-2706-5379)
- Ruining Sun
- Kunning Zhou (ORCID: https://orcid.org/0000-0002-2805-9317)
- Pixin Ran (ORCID: https://orcid.org/0000-0001-6651-634X)
- Erkang Yi (ORCID: https://orcid.org/0000-0002-1018-6641)
- Fan Wu (ORCID: https://orcid.org/0000-0003-0720-4674)
- Yü Liu (ORCID: https://orcid.org/0000-0003-2211-3535)
- Haiqing Li (ORCID: https://orcid.org/0000-0003-4075-9356)
- Qingyang Li (ORCID: https://orcid.org/0000-0003-1560-7270)
- Hairong Wang (ORCID: https://orcid.org/0009-0003-6835-0998)
- Zhishan Deng (ORCID: https://orcid.org/0009-0001-3836-7583)
- Xinru Ran (ORCID: https://orcid.org/0009-0003-4359-462X)
Institutions
- Guangzhou Experimental Station (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s12931-025-03238-1
- Citations
- 2
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China