Chemokine Receptor 2 Is a Theranostic Biomarker for Abdominal Aortic Aneurysms
Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a high mortality upon rupture. There is no diagnosis to predict the rupture nor effective medical therapies to prevent rupture. Here we demonstrate that the C-C chemokine receptor type 2 (CCR2) is a theranostic biomarker for AAA. In rat AAA models, we determined the potential of a CCR2-targeted positron emission tomography radiotracer [<sup>64</sup>Cu]Cu-DOTA-ECL1i predicting AAA rupture. Using a CCR2 inhibitor, we observed the effective prevention of rupture in AAA rat models. In humans, CCR2 positron emission tomography showed intense radiotracer uptake along the AAA wall in patients while little signal was observed in healthy volunteers.
Authors
- Robert J. Gropler (ORCID: https://orcid.org/0000-0002-6550-0570)
- Kory J. Lavine (ORCID: https://orcid.org/0000-0003-1948-9945)
- Xuefeng Gao (ORCID: https://orcid.org/0000-0002-1904-392X)
- Sergio Sastriques-Dunlop
- Joseph E. Ippolito (ORCID: https://orcid.org/0000-0003-1913-5573)
- Hannah Luehmann (ORCID: https://orcid.org/0000-0002-7516-6772)
- Andrea Bredemeyer (ORCID: https://orcid.org/0000-0003-2970-5998)
- Sean J. English
- Yeona Kang (ORCID: https://orcid.org/0000-0003-3384-435X)
- Deborah Sultan
- Chieh‐Yu Lin (ORCID: https://orcid.org/0000-0002-4269-3234)
- Xiaohui Zhang (ORCID: https://orcid.org/0000-0002-9259-5093)
- Batool Arif (ORCID: https://orcid.org/0009-0006-3610-0865)
- Dakkota Thies
- Richard A. Laforest (ORCID: https://orcid.org/0000-0002-0238-1439)
- Santiago Elizondo-Benedetto
- Kitty Harrison
- Lisa Detering (ORCID: https://orcid.org/0000-0001-7061-1024)
- Mohamed Zaghloul (ORCID: https://orcid.org/0000-0001-5061-0198)
- Christophe Combadière (ORCID: https://orcid.org/0000-0002-1755-4531)
- M.A. Zayed (ORCID: https://orcid.org/0000-0003-2425-6329)
- Jie Zheng (ORCID: https://orcid.org/0000-0003-4958-2091)
- Gyu Seong Heo (ORCID: https://orcid.org/0000-0001-6200-4742)
- Yongjian Liu (ORCID: https://orcid.org/0000-0002-1118-1535)
- Laura McDonald (ORCID: https://orcid.org/0000-0001-9846-7626)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Howard University (US)
- Inserm (FR)
- Washington University in St. Louis (US)
- Sorbonne Université (FR)
- Centre d'Immunologie et des Maladies Infectieuses (FR)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1016/j.jacbts.2025.02.010
- Citations
- 8
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 12.15
Funders
- Alvin J. Siteman Cancer Center
- National Institutes of Health
- Stephenson Cancer Center