Au Deposition Enhanced Fenton-like Chemistry within a Metal–Organic Framework

Chemodynamic therapy (CDT), which regulates oxidative stress in tumor tissues, has emerged as a promising alternative. However, the efficiency of MOF-based Fenton catalysts for CDT still needs improvement. This study presents a strategy to improve the Fenton catalytic performance of ZnCo-ZIF by depositing Au nanoparticles on its surface. Monodisperse ZnCo-ZIF particles (≤200 nm) were prepared by optimizing the Zn/Co ratio, and Au deposition enhanced electron transfer between Au and Co, increasing the charge density around Co atoms. This resulted in a 2.28-fold improvement in Fenton activity under acidic conditions and mild near-infrared (NIR) light. Loading the system with the natural product naringin (NA) molecule further demonstrated synergistic anticancer effects in vitro. This work offers insights into enhancing MOF-based catalysts for cancer therapy.