miR-145-enriched BMSCs-derived exosomes ameliorate neurogenic erectile dysfunction in aged rats via TGFBR2 inhibition
Exo-145 demonstrates superior efficacy compared to Exo in treating aged neurogenic ED by targeting TGFBR2 to alleviate apoptosis and fibrosis. It may represent a promising cell-free therapeutic option for neurogenic erectile dysfunction in elderly patients and could offer new perspectives for improving their prognosis.
Authors
- Wei Wang (ORCID: https://orcid.org/0000-0003-4472-9082)
- Bowen Tang (ORCID: https://orcid.org/0000-0002-1391-2522)
- Yunlong Ge (ORCID: https://orcid.org/0000-0002-9391-1780)
- Jianjie Wu (ORCID: https://orcid.org/0000-0002-7585-5201)
- Hengjun Xiao (ORCID: https://orcid.org/0000-0001-5472-2154)
- Yude Hong
- Bowen Zhang (ORCID: https://orcid.org/0000-0002-9129-5793)
- Hua Wang (ORCID: https://orcid.org/0000-0001-7110-3697)
- Jun Chen (ORCID: https://orcid.org/0000-0002-7180-2129)
- Tian Xia (ORCID: https://orcid.org/0000-0003-0733-0697)
- Yuhang Xi (ORCID: https://orcid.org/0009-0002-8722-0761)
- Zejia Feng
Institutions
- Sun Yat-sen University (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- University of South China (CN)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1016/j.reth.2025.04.004
- Citations
- 3
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Natural Science Foundation of China
- Guangzhou Municipal Science and Technology Project