Multiple Sclerosis–Specific Reference Curves for Brain Volumes to Explain Disease Severity
NBV values derived from an MS-specific reference model offer improved relevance for assessing disease severity compared with curves derived from age-specific and sex-specific HC reference models. Improving the model toward application in individual people could enhance clinical implementation.
Authors
- Bas Jasperse (ORCID: https://orcid.org/0000-0003-1577-8299)
- Bernard M.J. Uitdehaag (ORCID: https://orcid.org/0000-0002-9226-7364)
- Eva M. M. Strijbis (ORCID: https://orcid.org/0000-0001-6705-5864)
- Jeroen Hoogland (ORCID: https://orcid.org/0000-0002-2397-6052)
- Joost P.A. Kuijer (ORCID: https://orcid.org/0000-0002-4181-0427)
- Henk J. M. M. Mutsaerts (ORCID: https://orcid.org/0000-0003-0894-0307)
- Bastiaan Moraal (ORCID: https://orcid.org/0000-0003-4559-1118)
- Lizette Heine (ORCID: https://orcid.org/0000-0003-1369-8199)
- Len Bos (ORCID: https://orcid.org/0009-0006-7404-6716)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Hugo Vrenken (ORCID: https://orcid.org/0000-0001-9106-1172)
- Rozemarijn M. Mattiesing (ORCID: https://orcid.org/0000-0002-5876-4260)
- Menno Michiel Schoonheim (ORCID: https://orcid.org/0000-0002-2504-6959)
- Joep Killestein (ORCID: https://orcid.org/0000-0002-6347-5957)
- David Rudolf van Nederpelt (ORCID: https://orcid.org/0000-0003-0083-5238)
Institutions
- Amsterdam Neuroscience (NL)
- GGD Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1212/wnl.0000000000213618
- Citations
- 5
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- Amsterdam University Medical Centers
- National Institute for Health and Care Research
- ZonMw
- University College London Hospitals NHS Foundation Trust