Tumor-Infiltrating Clonal Hematopoiesis
TI-CH increased the risk of disease recurrence or death among patients with NSCLC and the risk of death from any cause among patients with solid tumors. TI-CH remodeled the tumor immune microenvironment and accelerated tumor organoid growth, findings that support a role for an aging-related hematologic clonal proliferation in cancer evolution. (Funded by the Royal Society and others.).
Authors
- Krijn K. Dijkstra (ORCID: https://orcid.org/0000-0002-5417-5397)
- Jennifer O’Sullivan (ORCID: https://orcid.org/0000-0003-0502-7133)
- Johanna A. Joyce (ORCID: https://orcid.org/0000-0002-6332-2598)
- Julian Downward (ORCID: https://orcid.org/0000-0002-2331-4729)
- Panayiotis Anastasiou (ORCID: https://orcid.org/0009-0002-9894-0537)
- Sergio A. Quezada (ORCID: https://orcid.org/0000-0002-9763-1700)
- Jayant K. Rane (ORCID: https://orcid.org/0000-0002-9594-3938)
- Simone Zaccaria (ORCID: https://orcid.org/0000-0002-5265-7392)
- Dominique A. Bonnet (ORCID: https://orcid.org/0000-0002-4735-5226)
- Elena Hoxha
- Aaron James Stonestrom (ORCID: https://orcid.org/0000-0002-0602-1158)
- Andreas Wack (ORCID: https://orcid.org/0000-0001-5226-2991)
- Rachel Scott (ORCID: https://orcid.org/0000-0001-5847-3378)
- Allan Hackshaw (ORCID: https://orcid.org/0000-0002-5570-5070)
- Katey S.S. Enfield (ORCID: https://orcid.org/0000-0002-4551-6073)
- Elsa Bernard (ORCID: https://orcid.org/0000-0002-2057-7187)
- Mary Green (ORCID: https://orcid.org/0009-0000-7437-7706)
- Charlotte Brierley (ORCID: https://orcid.org/0000-0002-4028-3733)
- Oriol Pich (ORCID: https://orcid.org/0000-0002-1956-1882)
- Sally‐Ann Clark (ORCID: https://orcid.org/0000-0003-1720-7975)
- Adam J. Mead (ORCID: https://orcid.org/0000-0001-8522-1002)
- Vittorio Barbè
- David R. Pearce (ORCID: https://orcid.org/0000-0001-8443-2924)
- Ángel F. Álvarez-Prado (ORCID: https://orcid.org/0000-0003-0622-2993)
- C. Donovan Bailey (ORCID: https://orcid.org/0000-0002-3123-4083)
- Alastair Magness
- Hector Huerga Encabo (ORCID: https://orcid.org/0000-0002-3723-8624)
- Robert E. Hynds (ORCID: https://orcid.org/0000-0002-2170-8791)
- Maria Zagorulya (ORCID: https://orcid.org/0000-0002-4478-5378)
- Supreet Kaur Bola (ORCID: https://orcid.org/0000-0001-8558-8197)
- Charles M. Rudin (ORCID: https://orcid.org/0000-0001-5204-3465)
- Rija Zaidi (ORCID: https://orcid.org/0000-0002-2259-4319)
- Eva Grönroos (ORCID: https://orcid.org/0000-0001-8303-5409)
- Kerstin Thol (ORCID: https://orcid.org/0000-0002-4624-118X)
- Ilaria Malanchi (ORCID: https://orcid.org/0000-0003-4867-3311)
- William Grey (ORCID: https://orcid.org/0000-0001-8209-5645)
- Steve Harris (ORCID: https://orcid.org/0000-0002-4982-1374)
- Cristina Lo Celso (ORCID: https://orcid.org/0000-0002-1163-4207)
- Constandina Pospori (ORCID: https://orcid.org/0000-0002-0587-1329)
- Elli Papaemmanuil (ORCID: https://orcid.org/0000-0003-1709-8983)
- Despoina Papazoglou (ORCID: https://orcid.org/0009-0008-5818-8663)
- Chrysante S. Iliakis (ORCID: https://orcid.org/0009-0000-4219-2950)
- Michael F. Berger
- Mariam Jamal-Hanjani
- Charles Swanton
- Ramy Slama
- Karl S. Peggs
- Andrew Rowan
Institutions
- University of Maryland, Baltimore (US)
- Memorial Sloan Kettering Cancer Center (US)
- University College London Hospitals NHS Foundation Trust (GB)
- The Francis Crick Institute (GB)
- Royal London Hospital (GB)
- Cancer Research UK (GB)
- Cancer Institute (WIA) (IN)
- Institut Gustave Roussy (FR)
- Centre Hospitalier Universitaire Vaudois (CH)
- The Netherlands Cancer Institute (NL)
- University of Oxford (GB)
- London Cancer (GB)
- MRC Weatherall Institute of Molecular Medicine (GB)
- Oncode Institute (NL)
- Ludwig Cancer Research (CH)
- UCL Biomedical Research Centre (GB)
- Immune Regulation (United Kingdom) (GB)
- Oxford University Hospitals NHS Trust (GB)
- CRUK Lung Cancer Centre of Excellence (GB)
- Swiss Cancer Center Léman (CH)
- Protéomique, Réponse Inflammatoire et Spectrométrie de Masse (FR)
- University College London (GB)
- Imperial College London (GB)
- University of York (GB)
- Medical Research Council (GB)
- University of Lausanne (CH)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1056/nejmoa2413361
- Citations
- 58
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 102.66
Funders
- National Science Foundation
- Damon Runyon Cancer Research Foundation
- European Molecular Biology Organization
- European Hematology Association
- Edward P. Evans Foundation
- Wellcome Trust
- Francis Crick Institute
- UK Research and Innovation
- Leukaemia UK
- Cancer Research UK
- National Institute for Health and Care Research
- Royal Society
- Kay Kendall Leukaemia Fund
- European Commission
- Agence Nationale de la Recherche
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- University College London Hospitals NHS Foundation Trust
- National Institutes of Health
- Horizon 2020 Framework Programme
- HORIZON EUROPE Framework Programme
- Medical Research Council
- European Research Council
- Clarendon Fund
- National Cancer Institute
- HORIZON EUROPE European Innovation Council