Portable multi-parametric microscopy for noninvasive metabolic and vascular imaging of orthotopic tongue cancer models in vivo

Our <i>in vivo</i> animal studies demonstrated the capability of our portable multi-parametric microscope for imaging the key metabolic and vascular parameters at the same tissue site with about one hour delay using an orthotopic tongue tumor model <i>in vivo</i>. Our study showed the potential of a portable functional microscope to noninvasively evaluate tumor biology using orthotopic tongue cancer models for future head and neck cancer research.