Genetic and transcriptional insights into immune checkpoint blockade response and survival: lessons from melanoma and beyond
This analysis identified potential molecular determinants of response and survival to ICI treatment. Insights from melanoma biomarker research hold significant promise for translation into other malignancies, guiding individualized anti-tumor immunotherapy.
Authors
- Xiaozhen Hu (ORCID: https://orcid.org/0000-0003-3890-0533)
- Kuo Zhao (ORCID: https://orcid.org/0000-0003-4557-4086)
- Qiuxiang Ou (ORCID: https://orcid.org/0000-0002-2961-2057)
- Yuxin Liang (ORCID: https://orcid.org/0000-0001-6872-5030)
- Hua Bao (ORCID: https://orcid.org/0000-0001-5774-8755)
- Song Wang (ORCID: https://orcid.org/0000-0002-8224-0424)
- Yanfeng Wang (ORCID: https://orcid.org/0000-0003-0859-3472)
- Youyu Wang (ORCID: https://orcid.org/0000-0003-3198-7568)
- Jiaxin Wen
Institutions
- Sinovac Biotech (CN)
- Chinese PLA General Hospital (CN)
- Lanzhou University Second Hospital (CN)
- Shenyang 242 Hospital (CN)
- Viva Biotech (China) (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s12967-025-06467-6
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.18