IQGAP-1 Mediated Activation of the Kupffer Cells Contributes to the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease
In conclusion, our research findings indicate that IQGAP-1 regulates the KCs-HSCs axis through multiple pathways, participating in the progression and exacerbation of MASLD, thus providing novel therapeutic targets for the treatment of MASLD.
Authors
- Jiye Luo
- Yongpeng Xie (ORCID: https://orcid.org/0000-0001-5787-5463)
- Chen Wang (ORCID: https://orcid.org/0009-0000-8614-7588)
- Xiaomin Li (ORCID: https://orcid.org/0000-0002-0051-3354)
- Xiaobing Chen (ORCID: https://orcid.org/0000-0003-4327-1209)
- Yan Sun (ORCID: https://orcid.org/0009-0003-8903-5954)
Institutions
- Lianyungang Oriental Hospital (CN)
- The First People’s Hospital of Lianyungang (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Shock
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1097/shk.0000000000002610
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00