Metformin induces apoptosis in pituitary-derived folliculostellate cells via the IL-6/ERK pathway
Metformin downregulates the expression of IL-6 in PDFS cells, inhibits the activation of the ERK pathway, thereby suppressing cell proliferation and PD-L1 expression, and induces cell apoptosis.
Authors
- Huitong Chen
- Xingyi Yuan
- Yuyou Luo
- Xin Wang (ORCID: https://orcid.org/0000-0001-8079-8638)
- Jing Liu (ORCID: https://orcid.org/0000-0002-7366-5287)
- Fan Dong (ORCID: https://orcid.org/0000-0001-6730-0612)
- Zongming Wang (ORCID: https://orcid.org/0000-0002-2885-1400)
- Zhongyu Wang (ORCID: https://orcid.org/0009-0004-2672-1559)
- Li Siyuan
Institutions
- Guangdong Pharmaceutical University (CN)
- Guangzhou Vocational College of Science and Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1007/s12672-025-02372-y
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00