Differential expression reveals inflammatory response and oxidative stress genes in dentin caries
This study reveals the role of inflammatory and oxidative stress-related genes in dentin caries and shows disruption in the ECM degradation-repair balance. Increased MMP-2 and TIMP-1 expression suggests a compensatory response. MMP activity may serve as a therapeutic target to enhance tissue resilience and slow caries progression.
Authors
- Alberto M. R. Dávila (ORCID: https://orcid.org/0000-0002-6918-7673)
- Rodrigo Jardim (ORCID: https://orcid.org/0000-0002-0943-5356)
- Flávio Henrique Baggio Aguiar (ORCID: https://orcid.org/0000-0003-3389-5536)
- Nelson Kotowski (ORCID: https://orcid.org/0000-0001-5397-7980)
- Karina Gonzáles Silvério (ORCID: https://orcid.org/0000-0001-5879-9095)
- Hélio Rodrigues Sampaio Filho (ORCID: https://orcid.org/0000-0003-4264-9118)
- Simone Gomes de Oliveira (ORCID: https://orcid.org/0000-0002-1414-3155)
Institutions
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Universidade do Estado do Rio de Janeiro (BR)
- Methodist University of Piracicaba (BR)
- Universidade Salgado de Oliveira (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Archives of Oral Biology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1016/j.archoralbio.2025.106274
- Citations
- 2
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 2.93