Distinct Role of TP53 Co-mutations in Different EGFR Subtypes Mediating the Response to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer
TP53 co-mutations are associated with poor survival and may cooperate with other genomic events to facilitate resistance in NSCLC harboring EGFR<sup>L858R</sup>. Sequential therapeutic interventions beyond EGFR-TKIs monotherapy may extend the survival of patients with EGFR<sup>L858R</sup>/TP53<sup>MT</sup>.
Authors
- Man Shu
- Jiahua Liu
- Tiantian Yang (ORCID: https://orcid.org/0000-0002-4185-9933)
- Lihong Wei
- Jianwen Zhou (ORCID: https://orcid.org/0000-0001-6729-1154)
- Huipin Wang
- Zhongpeng Xie (ORCID: https://orcid.org/0000-0003-1466-9795)
- Xu‐Chao Zhang (ORCID: https://orcid.org/0000-0002-4138-8115)
- Lihong Bai
- Zunfu Ke (ORCID: https://orcid.org/0000-0002-6251-7246)
- Yanxia Wang (ORCID: https://orcid.org/0000-0001-7691-4317)
- Xinwei Wang (ORCID: https://orcid.org/0000-0002-4862-0765)
- Tian Tian (ORCID: https://orcid.org/0000-0001-9763-9481)
- Yi Lao
- Qiong He (ORCID: https://orcid.org/0009-0002-5075-7856)
- Shuhua Li (ORCID: https://orcid.org/0000-0001-6756-057X)
- Tongze Fu
- Zheng Yang (ORCID: https://orcid.org/0000-0002-7081-6588)
- Juan Du (ORCID: https://orcid.org/0000-0002-4474-1199)
- Leilei Huang (ORCID: https://orcid.org/0009-0009-7342-5230)
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Central People's Hospital of Zhanjiang (CN)
- Zhongshan People's Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangdong Academy of Medical Sciences (CN)
Publication Details
- Journal
- Clinical Lung Cancer
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1016/j.cllc.2025.04.007
- Citations
- 5
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China