Effect of Acute Lung Injury (ALI) Induced by Lipopolysaccharide (LPS) on the Pulmonary Pharmacokinetics of an Antibody
ALI may significantly affect pulmonary PK of systemically administered antibodies. Changes caused by ALI are time and tissue dependent, and hence, the timing and dose of antibody following ALI may need to be optimized to maximize the therapeutic effect of the antibody at the site of action.
Authors
- Dhaval K. Shah (ORCID: https://orcid.org/0000-0002-0723-6206)
- Shweta Jogi
Institutions
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Antibodies
- Published
- 2025-04-06
- DOI
- https://doi.org/10.3390/antib14020033
- Citations
- 1
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases