Assessment of Patients With Beta‐Lactams Positive Provocation Tests by Biomarkers of <scp>IgG</scp> ‐Related Neutrophil Activation
Biomarkers of neutrophil activation and NETs were increased in BL IHRs with negative skin tests, positive sIgG and negative serum sIgE, and positive provocation test. We propose DNAse activity and NE as biomarkers for the biological assessment of BL IHRs and provocation tests and to consider IgG-related neutrophil activation as one of the mechanisms involved in BL IHRs with undetermined cause.
Authors
- Jean‐Marc Alberto (ORCID: https://orcid.org/0000-0002-5126-2890)
- Philippe Renard (ORCID: https://orcid.org/0000-0003-4504-435X)
- José Julio Laguna (ORCID: https://orcid.org/0000-0001-5909-8979)
- Cécile Lakomy
- Celine Chery
- Cosmin Boteanu (ORCID: https://orcid.org/0009-0007-1465-2017)
- Jean‐Louis Guéant (ORCID: https://orcid.org/0000-0002-5067-042X)
- Ramia Safar (ORCID: https://orcid.org/0000-0002-3545-1675)
- Huguette Louis (ORCID: https://orcid.org/0000-0002-5353-6832)
- Almut Heinken (ORCID: https://orcid.org/0000-0001-6938-8072)
- Rosa‐Maria Guéant‐Rodriguez (ORCID: https://orcid.org/0000-0003-1402-3716)
- Véronique Regnault (ORCID: https://orcid.org/0000-0001-6418-5022)
- Adrienne Astrid Gallizzi (ORCID: https://orcid.org/0009-0003-6124-5917)
- Antonino Romano (ORCID: https://orcid.org/0000-0003-3762-2084)
Institutions
- Inserm (FR)
- Oasi Maria SS (IT)
- Universidad Alfonso X el Sabio (ES)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Nutrition-Génétique et Exposition aux Risques Environnementaux (FR)
- Défaillance Cardiovasculaire Aiguë et Chronique
- Université de Lorraine (FR)
Publication Details
- Journal
- Clinical & Experimental Allergy
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1111/cea.70061
- Citations
- 3
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Instituto de Salud Carlos III