Chaperone-assisted E3 ligase-engineered mesenchymal stem cells target hyperglycemia-induced p53 for ubiquitination and proteasomal degradation ameliorates self-renewal
CHIP may promote ubiquitin-mediated proteasomal degradation of hyperglycemia-induced p53 rescues self-renewal genes, which can maintain the long-term undifferentiated state of WJMSCs. CHIP may be an alternative therapeutic option in regenerative medicine for hyperglycemic-related complications in diabetes.
Authors
- Marthandam Asokan Shibu (ORCID: https://orcid.org/0000-0001-6381-3525)
- Tsung-Jung Ho
- Chih‐Yang Huang (ORCID: https://orcid.org/0000-0003-2347-0411)
- Jeng‐Fan Lo (ORCID: https://orcid.org/0000-0001-7188-9140)
- Ayaz Ali (ORCID: https://orcid.org/0000-0003-4972-5515)
- Pei‐Ying Pai
- Chia‐Hua Kuo (ORCID: https://orcid.org/0000-0002-1731-4984)
- Shinn‐Zong Lin (ORCID: https://orcid.org/0000-0002-4601-9933)
- Wei‐Wen Kuo (ORCID: https://orcid.org/0000-0002-2097-2240)
- Dennis Jine-Yuan Hsieh (ORCID: https://orcid.org/0000-0002-7120-6140)
Institutions
- Bharathiar University (IN)
- Asia University (TW)
- National Yang Ming Chiao Tung University (TW)
- China Medical University (TW)
- Tzu Chi University (TW)
- University of Aberdeen (GB)
- University of Taipei (TW)
- Tzu Chi Foundation (TW)
- China Medical University Hospital (TW)
- Chung Shan Medical University (TW)
- National Yang Ming Chiao Tung University (TW)
Publication Details
- Journal
- Biological Research
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s40659-025-00604-7
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Asia University
- Buddhist Tzu Chi Medical Foundation
- China Medical University
- Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation