Establishment of a patient-derived 3D in vitro meningioma model in xeno-free hydrogel for clinical applications
Our patient-derived 3D meningioma models closely mimicked primary tumors in terms of cell morphology, immunohistochemical markers and genome-wide DNA methylation patterns, providing a cost-effective and accessible alternative to in vivo models. This approach has the potential to facilitate personalized treatment strategies for patients requiring additional therapy beyond surgery.
Authors
- Tiit Illimar Mathiesen (ORCID: https://orcid.org/0000-0001-9463-1919)
- Mikkel Schou Andersen (ORCID: https://orcid.org/0000-0003-4347-6626)
- Aaraby Nielsen (ORCID: https://orcid.org/0000-0003-2199-2857)
- Henning B. Boldt (ORCID: https://orcid.org/0000-0003-0569-0656)
- Birgitte Brinkmann Olsen (ORCID: https://orcid.org/0000-0002-6130-0387)
- Christopher Powell
- Morten Winkler Møller (ORCID: https://orcid.org/0000-0001-5677-0969)
- Grayson Herrgott
- Frantz Rom Poulsen (ORCID: https://orcid.org/0000-0001-5715-6901)
- Bo Halle (ORCID: https://orcid.org/0000-0001-9930-4490)
- Jeanette Krogh Petersen (ORCID: https://orcid.org/0000-0002-5093-5985)
- Charlotte Aaberg Poulsen (ORCID: https://orcid.org/0000-0003-1407-7976)
- Anavaleria Castro
- Christian Bonde Pedersen (ORCID: https://orcid.org/0000-0003-3761-0446)
- Martin Wirenfeldt (ORCID: https://orcid.org/0000-0001-9047-5787)
Institutions
- University of Copenhagen (DK)
- Henry Ford Health System (US)
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
- Rigshospitalet (DK)
- Karolinska Institutet (SE)
- Zealand University Hospital (DK)
- Region of Southern Denmark (DK)
- Hospital South West Jutland (DK)
- Michigan State University (US)
Publication Details
- Journal
- Acta Neuropathologica Communications
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s40478-025-02008-w
- Citations
- 2
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Syddansk Universitet