USP14 promotes osteoarthritis progression by deubiquitinating FZD8 to activate the Wnt/β-catenin signaling pathway
USP14 repressed IL-1β-treated chondrocyte proliferation and promoted apoptosis, inflammation and ECM degradation by regulating FZD8 expression and Wnt/β-catenin signal pathway.
Authors
- Huayi Wang (ORCID: https://orcid.org/0000-0001-6274-3844)
- Tiancheng Ma (ORCID: https://orcid.org/0000-0002-2444-1893)
- Qiang Sun (ORCID: https://orcid.org/0000-0002-5342-0637)
- Yaodong Wang (ORCID: https://orcid.org/0000-0002-9697-8673)
- Yongfeng Chen (ORCID: https://orcid.org/0000-0002-1360-9240)
- Xiaochao Chen (ORCID: https://orcid.org/0000-0002-3174-7778)
Institutions
- Xijing Hospital (CN)
Publication Details
- Journal
- Immunobiology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1016/j.imbio.2025.152905
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Key Research and Development Projects of Shaanxi Province