Effects of folic acid supplementation before conception on innate immunity and anti-HBs levels of offspring born to HBsAg-positive mothers
In conclusion, our findings demonstrate that preconception folic acid supplementation may enhance HepB vaccine responsiveness in infants of HBsAg-positive mothers. Meanwhile, high pNF-κB expression in cord blood can increase seropositive rates in infants. This discovery has significant public health implications, as it may provide a simple and accessible intervention to improve vaccination outcomes and reduce HBV transmission in endemic regions.
Authors
- Xiuyang Xu
- Tian Yao
- Men Zhe (ORCID: https://orcid.org/0000-0002-4283-8667)
- Yiqun Qu
- Suping Wang (ORCID: https://orcid.org/0000-0002-1476-5595)
- Jia Lian
- Yuping Li (ORCID: https://orcid.org/0000-0002-5833-931X)
- Jinbo Li (ORCID: https://orcid.org/0000-0002-7875-4369)
- Weigang Wang (ORCID: https://orcid.org/0000-0001-6911-1110)
- Yandi Li
- Yongliang Feng
Institutions
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
- Fourth People's Hospital of Taiyuan (CN)
- Taiyuan University of Technology (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-04-23
- DOI
- https://doi.org/10.3389/fnut.2025.1526053
- Citations
- 1
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China
- Shanxi Scholarship Council of China