Paraneoplastic itch

Summary This commentary presents information about paraneoplastic phenomena, with emphasis on paraneoplastic pruritus and its pathophysiology in the equine species. Pruritus that results from the development of underlying malignancy is often overlooked during the diagnostic and therapeutic management of affected equids. Unexplained pruritus should warrant consideration of a cancer diagnosis and, when appropriate, lead to expanded diagnostic testing in candidate patients. Earlier recognition of underlying cancer may lead to improved treatment outcomes or, in some cases, better welfare outcomes (euthanasia). The emerging role of interleukin‐31 as a principal mediator of itchiness (regardless of underlying aetiology) is leading to new research, with an eye to the availability of novel treatment approaches.