Anti-Microbial Activity of Secondary Metabolites and Extracts Originated from Rhizospheric Streptomyces sp.

Due to the intensive research for about 50 years from the early 1900s, the period from the 1940s, to the 1960s was considered the golden age of development of the antibiotics. However, from the last two decades, there has been no innovation in the development of antibiotics. One possible explanation is the vast majority of easily accessible terrestrial bacteria has been researched. Nevertheless, with advancements in scientific technology, research is progressing by studying terrestrial and marine samples that were previously inaccessible or by awakening dormant genes in previously obtained strains. However, these methods have not led to the development of antibiotics with new mechanisms. In this paper, we aim to present the potential of Streptomyces species, belonging to the phylum Actinomycetota, as a promising source for discovering antimicrobial compounds by summarizing studies that report their antimicrobial activity among strains derived from the plant rhizosphere.