Diminished SUV3 expression and its functional implications in the IFN-enriched monocyte subset of childhood Sjögren’s disease
SUV3 is the key driver for defective innate immune functions through mt-dsRNA-mediated PKR activation, which enhances cellular stress, mitochondrial dysfunction and inflammatory signatures, uncovering a novel mechanism in cSjD pathogenesis.
Authors
- Joon Paek
- Myung‐Chul Kim (ORCID: https://orcid.org/0000-0003-3389-1244)
- Daesong Jang
- Seunghee Cha (ORCID: https://orcid.org/0000-0003-3772-1832)
- Yoosik Kim (ORCID: https://orcid.org/0000-0003-3064-4643)
- Akaluck Thatayatikom (ORCID: https://orcid.org/0000-0001-7977-9237)
- Raquel Alvarado (ORCID: https://orcid.org/0000-0001-7250-2200)
- Rehae Miller
- Beatriz Veronese
- Jung‐Hoon Yoon (ORCID: https://orcid.org/0000-0002-3009-0962)
Institutions
- Korea Advanced Institute of Science and Technology (KR)
- AdventHealth Orlando (US)
- Santa Fe College (US)
- University of Florida (US)
- Kootenay Association for Science & Technology (CA)
- Jeju National University (KR)
- Florida College (US)
- Center for Autism and Related Disorders (US)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1093/rheumatology/keaf193
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87