An off-target effect of class A CpG-oligonucleotides on suppressing the cyclic GMP-AMP synthase signaling in fibroblastic reticular cells
Our data reveal an unrecognized off-target effect of class A ODN on suppressing the cGAS signaling in FRCs, which should be considered when designing class A ODN regimens for inflammatory diseases and cancer.
Authors
- Meihong Deng (ORCID: https://orcid.org/0000-0003-1901-347X)
- Hai Hui Huang (ORCID: https://orcid.org/0000-0001-7430-0119)
- Ting Jiang (ORCID: https://orcid.org/0000-0002-9757-7441)
- Preethi Jayakumar (ORCID: https://orcid.org/0000-0002-4961-6370)
Institutions
- Feinstein Institute for Medical Research (US)
- Hofstra University (US)
- Tsinghua University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.3389/fphar.2025.1576151
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Ohio State University
- National Institutes of Health
- Feinstein Institutes for Medical Research