Clusterin ameliorates diabetic atherosclerosis by suppressing macrophage pyroptosis and activation
Our study revealed that CLU could ameliorate diabetic atherosclerosis via suppressing inflammatory factors release and pyroptosis of macrophage. CLU may be a promising therapeutic target for diabetic atherosclerosis.
Authors
- Lingling Xuan (ORCID: https://orcid.org/0000-0002-8348-9969)
- Xin Kang (ORCID: https://orcid.org/0000-0002-1942-1652)
- Lili Gong (ORCID: https://orcid.org/0000-0002-0061-2029)
- Wen Zhang (ORCID: https://orcid.org/0000-0003-3150-2751)
- Lihong Liu (ORCID: https://orcid.org/0000-0003-4817-3173)
- Lulu Ren
- Rui Chang (ORCID: https://orcid.org/0000-0002-9820-8218)
Institutions
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- China-Japan Friendship Hospital (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.3389/fphar.2025.1536132
- Citations
- 4
- Primary Topic
- Clusterin in disease pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Natural Science Foundation of China