Lateral habenula astroglia modulate the potentiating antidepressant-like effects of bright light stimulation in intractable depression
These results reveal, for the first time, that BLS enhances the efficacy of antidepressants through an unexpectedly circuit involving rods, LHb astroglia and 5-HT.
Authors
- Renaud Rovera (ORCID: https://orcid.org/0000-0002-2017-1451)
- Satchidananda Panda (ORCID: https://orcid.org/0000-0002-7855-0091)
- April E. Williams (ORCID: https://orcid.org/0000-0001-9281-8528)
- Nasser Haddjeri (ORCID: https://orcid.org/0000-0002-2161-2204)
- Rihab Azmani
- Ouria Dkhissi‐Benyahya
- Olivier Raineteau (ORCID: https://orcid.org/0000-0003-4294-2496)
- Sarah Delcourte (ORCID: https://orcid.org/0000-0003-1904-177X)
- Hiep Dinh Le (ORCID: https://orcid.org/0000-0003-4147-6454)
- Amel Bouloufa (ORCID: https://orcid.org/0009-0009-6355-1137)
- Elie Brunet
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Salk Institute for Biological Studies (US)
- Inserm (FR)
- Institut Cellule Souche et Cerveau (FR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.3389/fphar.2025.1592909
- Citations
- 1
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Institute for Health and Care Research
- Agence Nationale de la Recherche
- Région Auvergne-Rhône-Alpes