Skeletal muscle microvascular hemodynamic responses during hyperinsulinemic-euglycemic clamp in a Zucker Diabetic Sprague Dawley rat model of type 2 diabetes
SD rats had a robust increase in capillary hemodynamics during hyperinsulinemic-euglycemic clamp whereas the capillary hemodynamics in ZDSD rats did not significantly change. Additionally, SD and ZDSD rats lacked expected hemodynamic responses in response to local [O<sub>2</sub>] changes during baseline and hyperinsulinemic-euglycemic clamp. This finding suggests that hyperglycemia in T2D and high-fat feeding alter microvascular hemodynamic responses to acute changes in muscle [O<sub>2</sub>].
Authors
- Gaylene M. Russell McEvoy
- Graham Fraser (ORCID: https://orcid.org/0000-0002-5733-201X)
- Hamza Shogan
- Meghan E. Kiley
- Brenda N. Wells
Institutions
- Memorial University of Newfoundland (CA)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.3389/fphys.2025.1568145
- Citations
- 1
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Canadian Institutes of Health Research