High B7-H3 protein expression in Medulloblastoma is associated with metastasis and unfavorable patient outcomes
This is the first study to associate CD276 mRNA and B7-H3 protein levels in MB, revealing a significant positive correlation. We observed that B7-H3 was overexpressed in MB compared to non-tumor brain tissue. High B7-H3 expression was associated with a worse outcome and with the presence of metastasis at diagnosis.
Authors
- Daniel Antunes Moreno (ORCID: https://orcid.org/0000-0002-0764-447X)
- Carlos Almeida Júnior
- João Norberto Stávale (ORCID: https://orcid.org/0000-0002-9141-0106)
- Bruna Minniti Mançano (ORCID: https://orcid.org/0000-0001-7489-4906)
- Gustavo Ramos Teixeira (ORCID: https://orcid.org/0000-0001-8363-3513)
- Rui Manuel Reis (ORCID: https://orcid.org/0000-0002-9639-7940)
- Patrícia Fontão (ORCID: https://orcid.org/0009-0005-0562-3148)
- Suzana Mária Fleury Malheiros (ORCID: https://orcid.org/0000-0003-3433-6867)
- Rui Ferreira Marques (ORCID: https://orcid.org/0000-0002-6713-6864)
Institutions
- Centro Universitário da Fundação Educacional de Barretos (BR)
- Hospital de Câncer de Barretos (BR)
- Instituto Barretos de Tecnologia (BR)
- Universidade Federal de São Paulo (BR)
- University of Minho (PT)
Publication Details
- Journal
- Diagnostic Pathology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s13000-025-01645-y
- Citations
- 4
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.50
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Ministério da Saúde
- Fundação para a Ciência e a Tecnologia