Age-Related Penetrance of Phospholamban p.Arg14del Cardiomyopathy
Penetrance of a major cardiac event is high in PLN p.(Arg14del) carriers, with a penetrance up to 70% at age 70. Penetrance of a cardiac risk factor is nearly complete at older age. Furthermore, cardiac phenotypes can emerge from adolescence to senior age. Life-long cardiac follow-up is needed, starting from adolescence.
Authors
- Arjan C. Houweling (ORCID: https://orcid.org/0000-0002-7728-7535)
- Freyja H.M. van Lint (ORCID: https://orcid.org/0000-0002-1787-4519)
- Virginnio Proost (ORCID: https://orcid.org/0000-0002-2658-3385)
- Juan Ramón Gimeno (ORCID: https://orcid.org/0000-0001-5818-1754)
- Remco de Brouwer (ORCID: https://orcid.org/0000-0002-5705-2034)
- Rudolf A. de Boer (ORCID: https://orcid.org/0000-0002-4775-9140)
- Folkert W. Asselbergs (ORCID: https://orcid.org/0000-0002-1692-8669)
- Cathelijne Dickhoff
- Tom E. Verstraelen (ORCID: https://orcid.org/0000-0002-4340-6815)
- Karim Taha (ORCID: https://orcid.org/0000-0001-6508-5461)
- Aeilko H. Zwinderman (ORCID: https://orcid.org/0000-0003-0361-3139)
- Paul A. van der Zwaag (ORCID: https://orcid.org/0000-0001-6693-0321)
- Laurens W. J. Bosman (ORCID: https://orcid.org/0000-0001-9497-0566)
- Maarten P. van den Berg (ORCID: https://orcid.org/0000-0002-1493-2998)
- Esmée van Drie (ORCID: https://orcid.org/0000-0002-6278-0626)
- Toon Oomen
- J. Peter van Tintelen (ORCID: https://orcid.org/0000-0003-3854-6749)
- Anneline S.J.M. te Riele (ORCID: https://orcid.org/0000-0002-4694-4790)
- Tjeerd Germans (ORCID: https://orcid.org/0000-0003-2781-0145)
- B. A. Schoonderwoerd
- Arthur A.M. Wilde
- Lotte Weverink
- Thais Bueren
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Utrecht University (NL)
- Medisch Centrum Leeuwarden (NL)
- University Medical Center Utrecht (NL)
- Noordwest Ziekenhuisgroep (NL)
- St. Antonius Ziekenhuis (NL)
- Amsterdam Neuroscience (NL)
- ERN GUARD-Heart (NL)
- Westfriesgasthuis (NL)
- Hospital Universitario Virgen de la Arrixaca (ES)
- Amsterdam University Medical Centers (NL)
- Amsterdam University of Applied Sciences (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1002/ejhf.3672
- Citations
- 4
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- European Society of Cardiology
- Fondation Leducq