Reduced dose direct oral anticoagulants and time-in-therapeutic-range defined warfarin in new-onset atrial fibrillation: a report from the nationwide FinACAF study
DOACs with reduced doses are efficient and safe stroke prevention therapy in high-risk patients with AF when compared with warfarin therapy of sufficient TTR. In this comparison, warfarin therapy of excellent TTR-quality was associated with the lowest risk of bleeding and mortality.
Authors
- Konsta Teppo (ORCID: https://orcid.org/0000-0002-4460-0994)
- Pirjo Mustonen (ORCID: https://orcid.org/0000-0003-1319-0248)
- Juhani K.E. Airaksinen (ORCID: https://orcid.org/0000-0002-0193-568X)
- Juha E.K. Hartikainen (ORCID: https://orcid.org/0000-0003-0847-107X)
- Miika Linna (ORCID: https://orcid.org/0000-0002-7660-2484)
- Aapo L. Aro (ORCID: https://orcid.org/0000-0001-7030-6740)
- Gregory Y.H. Lip (ORCID: https://orcid.org/0000-0002-7566-1626)
- Mikko Niemi (ORCID: https://orcid.org/0000-0003-4550-2189)
- Alex Luojus (ORCID: https://orcid.org/0000-0001-7119-2781)
- Olli Halminen (ORCID: https://orcid.org/0000-0001-9266-8435)
- Jukka Putaala A (ORCID: https://orcid.org/0000-0002-6630-6104)
- Jari K. Haukka (ORCID: https://orcid.org/0000-0003-1450-6208)
- Mika Lehto (ORCID: https://orcid.org/0000-0002-8691-5142)
- Ossi Lehtonen (ORCID: https://orcid.org/0009-0009-4914-1027)
- Jaana Kuoppala
Institutions
- University of Helsinki (FI)
- Medical University of Białystok (PL)
- University of Liverpool (GB)
- University of Turku (FI)
- University of Eastern Finland (FI)
- Helsinki University Hospital (FI)
- Jorvi Hospital (FI)
- Turku University Hospital (FI)
- Liverpool Heart and Chest Hospital (GB)
- Kuopio University Hospital (FI)
- Finland University (FI)
- Hospital District of Helsinki and Uusimaa (FI)
- Liverpool John Moores University (GB)
- Aalborg University (DK)
- Aalto University (FI)
Publication Details
- Journal
- European Heart Journal Open
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1093/ehjopen/oeaf046
- Citations
- 1
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Foundation for Cardiovascular Research
- Yrjö Jahnssonin Säätiö
- Aarne Koskelon Säätiö
- Kela
- Sydäntutkimussäätiö