Divergent gene signatures and neutrophil enrichment in lymph nodes of inflammatory arthritis patients
This study provides novel insights into the immune landscape of lymph nodes in inflammatory arthritis, emphasizing an unexpected role for neutrophils in IA patients. Future research should explore the functional implications of neutrophils within these uninfected lymph nodes to better understand their contribution to the pathogenesis of inflammatory arthritis.
Authors
- Chaja M. J. van Ansenwoude
- Aldo Jongejan (ORCID: https://orcid.org/0000-0002-8948-2549)
- Perry D. Moerland (ORCID: https://orcid.org/0000-0002-2357-3659)
- Aoife M. O’Byrne (ORCID: https://orcid.org/0000-0001-8185-2501)
- Mario Maas (ORCID: https://orcid.org/0000-0001-6785-5167)
- Janne W. Bolt (ORCID: https://orcid.org/0000-0001-5065-7439)
- Lisa G. M. van Baarsen (ORCID: https://orcid.org/0000-0003-3346-8921)
- Johanna F. Semmelink
- Marleen G H van de Sande (ORCID: https://orcid.org/0000-0003-0966-878X)
- Martijn van der Heijde
Institutions
- Netherlands Center for Occupational Diseases (NL)
- Amsterdam Neuroscience (NL)
- GGD Amsterdam (NL)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s13075-025-03557-0
- Citations
- 4
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Horizon 2020