Effects of lacto-vegetarian and vegan diets on glycemic responses and metabolite profiles in healthy adults: A randomized trial using continuous glucose monitoring and targeted metabolomics
Our pilot CGM data suggest a lacto-vegetarian diet may offer better glycemic control, potentially explained by our preliminary metabolomics findings. The increased Phe observed in the vegan group may be explained by a hypothetical mechanism in which higher glucose induces oxidative stress, whereas the increased C2 from dairy in the lacto-vegetarian group may protect against oxidative stress, contributing to lower glucose concentrations. However, larger, longer-term studies with more diverse populations, along with in vitro investigations into biomolecular mechanisms, are needed to confirm these findings.
Authors
- Ranjit Mohan Anjana (ORCID: https://orcid.org/0000-0002-4843-1374)
- Anisha Wijeyesekera (ORCID: https://orcid.org/0000-0001-6151-5065)
- Viswanathan Mohan (ORCID: https://orcid.org/0000-0001-5038-6210)
- Kuzhanthaivelu Abirami
- D.I. Givens (ORCID: https://orcid.org/0000-0002-6754-6935)
- Karani Santhanakrishnan Vimaleswaran (ORCID: https://orcid.org/0000-0002-8485-8930)
- Valangaiman Sriram Manasa (ORCID: https://orcid.org/0009-0005-3019-789X)
- Xianyu Zhu
- Vasudevan Sudha (ORCID: https://orcid.org/0000-0003-1382-0609)
- Shilpa N Bhupathiraju (ORCID: https://orcid.org/0000-0001-9910-6777)
- Rajagopal Gayathri (ORCID: https://orcid.org/0000-0002-6195-8584)
Institutions
- Brigham and Women's Hospital (US)
- Madras Diabetes Research Foundation (IN)
- University of Reading (GB)
Publication Details
- Journal
- Clinical Nutrition
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1016/j.clnu.2025.04.018
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- University of Reading