Involvement of TRPV1 and MOR-NMDAR complex on the antiallodynic effect of LMH-2, a sigma-1 receptor antagonist, in mouse model of diabetic neuropathy - a behavioral approach
These results suggest the potential utility of LMH-2 in the treatment of diabetic neuropathy and highlight a key role for TRPV1 in LMH-2's antiallodynic mechanism, along with a possible, albeit limited, interaction with the MOR/NMDA complex.
Authors
- María Eva González-Trujano (ORCID: https://orcid.org/0000-0002-4399-1508)
- Myrna Déciga‐Campos (ORCID: https://orcid.org/0000-0002-1467-9486)
- Rosa Ventura‐Martínez (ORCID: https://orcid.org/0000-0002-6580-2886)
- Guadalupe Esther Ángeles‐López (ORCID: https://orcid.org/0000-0003-0518-7620)
- Gabriel Navarrete‐Vázquez (ORCID: https://orcid.org/0000-0001-5344-4762)
- Tania Domínguez-Páez (ORCID: https://orcid.org/0009-0009-5971-5813)
- Wendy Arratia-Damián
Institutions
- Universidad Autónoma de la Ciudad de México (MX)
- Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (MX)
- Instituto Politécnico Nacional (MX)
- Universidad Autónoma del Estado de Morelos (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Pharmacological Reports
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1007/s43440-025-00727-4
- Primary Topic
- Pharmacological Receptor Mechanisms and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto Politécnico Nacional
- Consejo Nacional de Ciencia y Tecnología
- Secretaría de Investigación y Posgrado, Instituto Politécnico Nacional
- Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México