Maternal Anaemia and Congenital Heart Disease in Offspring: A Case–Control Study Using Linked Electronic Health Records in the United Kingdom
The observed association between maternal anaemia in early pregnancy and increased risk of offspring CHD supports our recent evidence in mice. Approximately two-thirds of anaemia cases globally are due to iron deficiency. A clinical trial of periconceptional iron supplementation might be a minimally invasive and low-cost intervention for the prevention of some CHD if iron deficiency anaemia is proven to be a cause.
Authors
- Manisha Nair (ORCID: https://orcid.org/0000-0003-0660-5054)
- Margaret Smith (ORCID: https://orcid.org/0000-0002-0946-742X)
- Duncan B. Sparrow (ORCID: https://orcid.org/0000-0002-1141-6613)
- Clare Bankhead (ORCID: https://orcid.org/0000-0003-1588-3849)
- Cynthia Wright (ORCID: https://orcid.org/0000-0002-7196-1509)
Institutions
- University of Oxford (GB)
Publication Details
- Journal
- BJOG An International Journal of Obstetrics & Gynaecology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1111/1471-0528.18150
- Citations
- 1
- Primary Topic
- Cardiovascular Issues in Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- Medical Research Council
- National Institute for Health and Care Research Applied Research Collaboration Oxford and Thames Valley