Systemic Inflammation and Anhedonic Responses to an Inflammatory Challenge in Adults With Major Depressive Disorder: A Randomized Controlled Trial
Depressed individuals with systemic inflammation appeared to be biologically primed to respond more strongly to inflammatory stimuli, and psychologically, this sensitization impacted the symptom of anhedonia, the primary outcome.
Authors
- Michael R. Irwin (ORCID: https://orcid.org/0000-0002-1502-8431)
- Sahib S. Khalsa (ORCID: https://orcid.org/0000-0003-2124-8585)
- Salvador Guinjoan
- Leandra K. Figueroa‐Hall (ORCID: https://orcid.org/0000-0003-1898-9868)
- Jonathan Savitz (ORCID: https://orcid.org/0000-0001-8143-182X)
- Yoon‐Hee Cha (ORCID: https://orcid.org/0000-0003-3804-0879)
- Rayus Kuplicki (ORCID: https://orcid.org/0000-0003-2954-6421)
- MacGregor Thomas
- Haixia Zheng (ORCID: https://orcid.org/0000-0002-5262-6676)
- Nour El-Sabbagh
- Kaiping Burrows (ORCID: https://orcid.org/0000-0003-2324-9012)
- Hung‐Wen Yeh (ORCID: https://orcid.org/0000-0002-9904-3275)
- Martin P. Paulus (ORCID: https://orcid.org/0000-0002-0825-3606)
- T. Kent Teague
- Isaac Ewers
Institutions
- Tulsa Community College (US)
Publication Details
- Journal
- American Journal of Psychiatry
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1176/appi.ajp.20240142
- Citations
- 12
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.93