Active EBV infection in children: associations between DNA load, infection status, immune status, and disease severity
An elevated EBV DNA load (> 1 × 10<sup>5</sup> copies/mL) in children is associated with increased mortality risk. High pro-inflammatory and anti-inflammatory states, coupled with low immune cell numbers, indicate critical condition. Simultaneous examinations of EBV DNA, antibodies, and immune status are recommended, especially for children with EBV DNA > 1 × 10<sup>5</sup> copies/mL, emphasizing the need for caution in those with activation-IgG<sup>+</sup> and immune dysregulation.
Authors
- Xiaohui Zeng (ORCID: https://orcid.org/0000-0001-6050-4137)
- Lan Luo (ORCID: https://orcid.org/0000-0002-1314-4367)
- Yufan Yang (ORCID: https://orcid.org/0000-0001-6148-8570)
- Xiulan Lu (ORCID: https://orcid.org/0000-0003-3328-5623)
- Longlong Xie (ORCID: https://orcid.org/0000-0002-5690-9083)
- Zhenghui Xiao (ORCID: https://orcid.org/0000-0001-6308-9688)
- Xiangyu Wang (ORCID: https://orcid.org/0000-0001-8605-0727)
- Xiao Li (ORCID: https://orcid.org/0000-0001-9420-9558)
- Ting Luo (ORCID: https://orcid.org/0000-0001-9353-3671)
- Haipeng Yan
Institutions
- Central South University (CN)
- Hunan Children's Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s12985-025-02741-7
- Citations
- 1
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China
- Hunan Provincial Science and Technology Department
- Natural Science Foundation of Hunan Province