Bidirectional Mendelian randomization reveals associations between telomere length and autoimmune diseases
This Mendelian randomization analysis reveals a significant association between telomere length and autoimmune diseases such as RA, GD, and psoriasis, while a positive relationship was validated with SLE. These findings underscore the need for further investigation to better understand the underlying mechanisms and their potential clinical applications.
Authors
- Chenxi Yu (ORCID: https://orcid.org/0000-0002-2813-9528)
- Shiben Zhu (ORCID: https://orcid.org/0000-0002-0846-0453)
- Yang Liu (ORCID: https://orcid.org/0000-0002-6579-3633)
- Min Ye
- Qin Jiang (ORCID: https://orcid.org/0000-0001-8622-7780)
Institutions
- Hubei University of Chinese Medicine (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
- Nanfang Hospital (CN)
- Shenzhen Bao'an District People's Hospital (CN)
- Shenzhen Children's Hospital (CN)
- Southern Medical University (CN)
- Hubei University (CN)
Publication Details
- Journal
- Trials
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s13063-025-08831-9
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00