MicroRNA-210 Mediates Hypoxic Pulmonary Hypertension in the Newborn Lamb
We provide explicit evidence that neonatal hypoxia increases microRNA-210 expression, which is essential for suppression of STOCs, resulting in pulmonary hypertension in newborn lambs. Our study reveals new insights into the mechanisms and clinically meaningful targets for treatment of pulmonary hypertension of the newborn.
Authors
- Chiranjib Dasgupta
- Rui Song
- Shawn Hanson
- Arlin B. Blood (ORCID: https://orcid.org/0000-0002-4803-5021)
- Abu Ahmed (ORCID: https://orcid.org/0000-0002-7931-8972)
- Taiming Liu (ORCID: https://orcid.org/0000-0003-1451-7951)
- Xiang‐Qun Hu (ORCID: https://orcid.org/0000-0003-1626-9541)
- Li Zhang (ORCID: https://orcid.org/0000-0002-9386-8938)
- Stephen Twum‐Barimah
Institutions
- Loma Linda University (US)
Publication Details
- Journal
- Hypertension
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1161/hypertensionaha.124.23061
- Citations
- 1
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52