Evaluating and mitigating bias in AI-based medical text generation

Artificial intelligence (AI) systems, particularly those based on deep learning models, have increasingly achieved expert-level performance in medical applications. However, there is growing concern that such AI systems may reflect and amplify human bias, reducing the quality of their performance in historically underserved populations. The fairness issue has attracted considerable research interest in the medical imaging classification field, yet it remains understudied in the text-generation domain. In this study, we investigate the fairness problem in text generation within the medical field and observe substantial performance discrepancies across different races, sexes and age groups, including intersectional groups, various model scales and different evaluation metrics. To mitigate this fairness issue, we propose an algorithm that selectively optimizes those underserved groups to reduce bias. Our evaluations across multiple backbones, datasets and modalities demonstrate that our proposed algorithm enhances fairness in text generation without compromising overall performance.

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Publication Details

Journal
Nature Computational Science
Published
2025-04-23
DOI
https://doi.org/10.1038/s43588-025-00789-7
Citations
7
Primary Topic
Artificial Intelligence in Healthcare and Education
Type
article
Field-Weighted Citation Impact
4.58
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article

Evaluating and mitigating bias in AI-based medical text generation

Xiangliang Zhang, Zirui Song, Xiuying Chen, Juexiao Zhou et al.
7 citations
Nature Computational Science
Artificial Intelligence in Healthcare and Education
4.58
article

Evaluating and mitigating bias in AI-based medical text generation

Xiangliang Zhang, Zirui Song, Xiuying Chen, Juexiao Zhou, Xin D. Gao, Tairan Wang
article en
7 citations

Abstract

Artificial intelligence (AI) systems, particularly those based on deep learning models, have increasingly achieved expert-level performance in medical applications. However, there is growing concern that such AI systems may reflect and amplify human bias, reducing the quality of their performance in historically underserved populations. The fairness issue has attracted considerable research interest in the medical imaging classification field, yet it remains understudied in the text-generation domain. In this study, we investigate the fairness problem in text generation within the medical field and observe substantial performance discrepancies across different races, sexes and age groups, including intersectional groups, various model scales and different evaluation metrics. To mitigate this fairness issue, we propose an algorithm that selectively optimizes those underserved groups to reduce bias. Our evaluations across multiple backbones, datasets and modalities demonstrate that our proposed algorithm enhances fairness in text generation without compromising overall performance.

Nature Computational ScienceVol. 5(5)
University of Notre Dame (US), Mohamed bin Zayed University of Artificial Intelligence (AE), King Abdullah University of Science and Technology (SA)
Quality Education
Openalex Percentile: Top 5%
Artificial Intelligence in Healthcare and Education
4.58
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Evaluating and mitigating bias in AI-based medical text generation — Xiangliang Zhang, Zirui Song, et al. · Nature Computational Science (2025) | TGRS Research Map | TGRS