Temporal evolution and factors influencing visual function and RNFL thickness in ethambutol-associated optic neuropathy

This study identifies a critical recovery window for visual function in EON between 3 and 6 months, with peripapillary retinal nerve fiber layer thinning progressing significantly between 3 and 9 months. The temporal quadrant of the peripapillary retinal nerve fiber layer may serve as an early marker for disease progression. These findings provide valuable insights for optimizing monitoring and intervention strategies in EON patients, highlighting that early therapeutic interventions-particularly for patients showing temporal RNFL thinning or high-risk features-may maximize visual recovery potential.