Methylglyoxal Reshapes Hepatic and Adipose Tissue Metabolism and Increases Viability of Lymphocytes
To what degree the modifications in hepatic metabolism found in MG-exposed rats can be translated to patients with a high-grade inflammation and cirrhosis is uncertain. However, it is unlikely that the strong catabolic state induced by MG would not contribute in some way to the hepatic dysfunction in advanced liver diseases.
Authors
- Jurandir Fernando Comar (ORCID: https://orcid.org/0000-0002-9518-7589)
- Verônica Elisa Pimenta Vicentini (ORCID: https://orcid.org/0000-0003-1385-0058)
- Mariane Aparecida Franco de Godoy (ORCID: https://orcid.org/0000-0003-4186-5855)
- Silvano Piovan (ORCID: https://orcid.org/0000-0002-0314-3838)
- Adelar Bracht (ORCID: https://orcid.org/0000-0002-8098-5705)
- Lucas Paulo Jacinto Saavedra (ORCID: https://orcid.org/0000-0003-0825-426X)
- Rogério Marchiosi (ORCID: https://orcid.org/0000-0002-8386-2524)
- Lívia Bracht (ORCID: https://orcid.org/0000-0003-3315-3540)
- Emanuele Parreira de Lima
- Naiara Cristina Lucredi (ORCID: https://orcid.org/0000-0003-4565-8028)
- Anacharis Babeto de Sá‐Nakanishi (ORCID: https://orcid.org/0000-0002-2300-1861)
- Claudia C.S. Chini
- Paulo Cézar de Freitas Mathias (ORCID: https://orcid.org/0000-0001-6994-4585)
Institutions
- Universidade Estadual de Maringá (BR)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Cellular Physiology and Biochemistry
- Published
- 2025-04-21
- DOI
- https://doi.org/10.33594/000000770
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Glenn Foundation for Medical Research
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fondation pour la Recherche Médicale
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- National Cancer Institute