Thromboembolism risk of Janus kinase inhibitors with concurrent oral contraceptive use: a global multicentre cohort study
This retrospective cohort study assessed venous thromboembolism (VTE) risk in female patients with alopecia areata and atopic dermatitis on Janus kinase inhibitors (JAKi) with or without concurrent combined oral contraceptive pill (COCP) use. No significant differences in deep vein thrombosis, pulmonary embolism or overall VTE risk were observed between cohorts, and the absolute VTE risk remained low in both groups. These findings suggest that COCP use does not significantly compound JAKi-associated VTE risk, providing reassurance for patients requiring both therapies.
Authors
- Rahib K. Islam (ORCID: https://orcid.org/0000-0001-8175-4290)
- Lillian Mo (ORCID: https://orcid.org/0009-0004-7176-3360)
- Shari R. Lipner (ORCID: https://orcid.org/0000-0001-5913-9304)
- Jordan Talia (ORCID: https://orcid.org/0000-0003-1113-4891)
- Benjamin Ungar (ORCID: https://orcid.org/0000-0003-0882-8163)
- Jónas A. Aðalsteinsson (ORCID: https://orcid.org/0000-0002-1159-6159)
- Nicholas Gulati
- Jasmine Levine
Institutions
- Cornell University (US)
- Weill Cornell Medicine (US)
- Louisiana State University Health Sciences Center New Orleans (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Clinical and Experimental Dermatology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1093/ced/llaf178
- Primary Topic
- Urticaria and Related Conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00