Protein Induced by Vitamin K Antagonist-II (PIVKA-II) Sebagai Tumor Marker Pada Karsinoma Sel Hati

Liver cell carcinoma (KSH) is a primary malignant liver tumor originating from hepatocyte cells that grow abnormally and is the most common primary liver cancer. Even though there are quite a lot of surveillance methods and diagnostic guidelines for KSH, only 40% of KSH cases are diagnosed at an early stage. Detecting KSH at an early stage is an effective way to increase the long-term survival rate of KSH patients. One way to detect KSH early is by examining tumor markers in at-risk populations. Protein induced by vitamin K antagonist-II (PIVKA-II) is a tumor marker that can be used to replace the role of Alpha-fetoprotein (AFP) not only for surveillance, but also in the diagnosis and prognosis of KSH and from several studies, PIVKA-II is superior with higher sensitivity and specificity than AFP which is a conventional KSH tumor marker.