Protease-activated Receptor 2 Promotes Crohn's Disease-Associated Colonic Fibrosis through Fibroblast Activation
Our results show that PAR-2 activation could upregulate extracellular matrix (ECM) proteomic levels, encourage CF, and cause a pro-fibrogenic phenotype within human colonic myofibroblasts.
Authors
- Chenghao Chu (ORCID: https://orcid.org/0000-0002-4339-9221)
- Bin Liu (ORCID: https://orcid.org/0000-0001-7890-7612)
- Zhaohui Wang (ORCID: https://orcid.org/0000-0001-7994-7464)
- Fubao Liu (ORCID: https://orcid.org/0000-0003-3431-2187)
Institutions
- Anhui Medical University (CN)
- Anqing City Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Current Molecular Medicine
- Published
- 2025-04-23
- DOI
- https://doi.org/10.2174/0115665240351860250403112214
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00