Scaffold Hopping and Optimization of Thiazole Hybrids as Selective PIN1 Inhibitors: A Computational Study
The results corroborated the docking outcomes, validating the selected hits as potential PIN1 inhibitors. This breakthrough could influence the development of therapeutic leads for combating diabetes, cancer, and Alzheimer's disease.
Authors
- Soumya Vasu
- M. K. Kathiravan
- Meeramol C. Chellappan
- J. Saravanan (ORCID: https://orcid.org/0000-0001-9307-2692)
- Shriraam Mahadevan (ORCID: https://orcid.org/0000-0002-6915-5639)
- Knolin K. Thachil (ORCID: https://orcid.org/0000-0002-9967-6048)
- Soniya Naik
Institutions
- JSS Academy of Higher Education and Research (IN)
- SRM Institute of Science and Technology (IN)
- Sri Ramachandra Institute of Higher Education and Research (IN)
- M S Ramaiah University of Applied Sciences (IN)
- Sri Ramachandra Medical Centre (IN)
Publication Details
- Journal
- Medicinal Chemistry
- Published
- 2025-04-23
- DOI
- https://doi.org/10.2174/0115734064376657250416071044
- Primary Topic
- Educational Methods and Media Use
- Type
- article
- Field-Weighted Citation Impact
- 0.00