Dissolving microneedles fabricated from 3D-printed master molds for application in veterinary medicine

Microneedle (MN) technology is gaining popularity as it offers many benefits and advantages over the conventional drug delivery methods. The transdermal drug delivery system (TDDS) with MNs offers painless, precise, and easy-to-use solutions that can be obtained using cost-effective technologies such as 3D printing. Numerous examples of microneedle applications have been reported for human use, especially given the context of the recent pandemic and the development of vaccination technologies. However, there is limited exploration of microneedles in veterinary medicine. In the following work, we presented a proposal for the efficient production of quickly dissolving microneedle patches from PVP (polyvinylpyrrolidone) and PVA (polyvinyl alcohol) polymers based on a model microneedle array printed using DLP (Digital Light Processing) technology. We have developed a repeatable process in which the obtained microneedles can easily penetrate the outer layers of skin and quickly deliver the model drug. Such a versatile platform can be used, among others, in the treatment of animal gingival diseases, which affect a significant amount of the cat and dog population. An important advantage of the presented solution is the possibility of implementing the whole technological process in a veterinary office in a short time and the possibility of easy adjusting the size of the patches to a specific animal.