The protective role of aqueous extract of rosemary leaves and vitamin E in protection against risk of induced hyperlipidemia in male white rats

The study aimed to determine the protective effect of the aqueous extract of rosemary leaves and vitamin E against induced hyperlipidemia on some biochemical parameters in serum and aortic tissue in male white rats. Twenty rats weighing 250-300 g and aged 10-12 weeks were used and placed in plastic cages under laboratory conditions for 30 days. The animals were divided into four groups: the first was the control group fed a standard diet, the second was fed a standard diet with cholesterol (1% g/kg), the third was fed cholesterol with vitamin E (50 mg/kg), and the fourth was fed cholesterol with the aqueous extract (50 mg/kg). The results showed that the cholesterol diet caused a significant increase (P < 0.01) in TG, LDL, VLDL, and HDL levels, while treatment with the aqueous extract and the extract with vitamin E resulted in a significant decrease in TC, TG, LDL, VLDL, and HDL levels. The reduction was more pronounced in the group treated with the extract and vitamin E. Additionally, the treatment improved aortic tissue compared to the cholesterol group. The study concludes the preventive role of rosemary aqueous extract and vitamin E against the harmful effects of elevated lipid levels.