Plasma Glial Fibrillary Acidic Protein and Neurofilament Light Are Elevated in Bipolar Depression: Evidence for Neuroprogression and Astrogliosis
These findings indicate increased plasma NfL and GFAP levels in bipolar disorder. Our findings support the neuroprogression hypothesis, where prolonged illness duration contributes to neuroaxonal damage. Elevated GFAP in those with later onset suggests a role for neuroinflammation, potentially linked to increased cardiovascular and metabolic comorbidities.
Authors
- Charles Benjamin Malpas (ORCID: https://orcid.org/0000-0003-0534-3718)
- Christos Pantelis (ORCID: https://orcid.org/0000-0002-9565-0238)
- Claudia Cicognola (ORCID: https://orcid.org/0000-0003-1806-7089)
- Adam J. Walker (ORCID: https://orcid.org/0000-0002-5399-1245)
- Olivia Dean (ORCID: https://orcid.org/0000-0002-2776-3935)
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Matthew Kang (ORCID: https://orcid.org/0000-0001-9375-3762)
- Dhamidhu Eratne (ORCID: https://orcid.org/0000-0002-3226-7645)
- Dennis Velakoulis (ORCID: https://orcid.org/0000-0002-8842-8479)
- Malcolm Hopwood (ORCID: https://orcid.org/0000-0001-6004-4521)
- Michael Berk (ORCID: https://orcid.org/0000-0002-5554-6946)
- Cassandra M. J. Wannan (ORCID: https://orcid.org/0000-0003-1317-4635)
- Alexander Santillo (ORCID: https://orcid.org/0000-0001-9717-0820)
- Philip Bowden Mitchell (ORCID: https://orcid.org/0000-0002-7954-5235)
- Jasleen Grewal (ORCID: https://orcid.org/0009-0003-8281-2597)
- Shorena Janelidze
Institutions
- The Royal Melbourne Hospital (AU)
- Barwon Health (AU)
- Deakin University (AU)
- The University of Melbourne (AU)
- Lund University (SE)
- Florey Institute of Neuroscience and Mental Health (AU)
- UNSW Sydney (AU)
- Orygen (AU)
- Western Health (AU)
- Sunshine Hospital (AU)
- Skåne University Hospital (SE)
- Melbourne Clinic (AU)
- Alfred Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Bipolar Disorders
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1111/bdi.70029
- Citations
- 5
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- Alzheimer's Association
- Australian Government
- GHR Foundation
- University of Melbourne
- Lunds Universitet
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse
- Skånes universitetssjukhus
- Parkinsonfonden
- Medical Research Council
- National Health and Medical Research Council