Impact of the inoculum effect on cefepime activity against AmpC-hyperproducing <i>Enterobacter</i> spp.: insights into resistance mechanisms
These findings highlight the critical impact of bacterial inoculum size on cefepime efficacy in AmpC-hyperproducing Enterobacter spp. infections. Tailored antimicrobial strategies are needed, especially for infections with high bacterial loads, to optimize clinical outcomes and minimize resistance development.
Authors
- José Miguel Cisneros (ORCID: https://orcid.org/0000-0001-5001-672X)
- Ángel Rodríguez-Villodres (ORCID: https://orcid.org/0000-0001-6373-9724)
- Adelina Gimeno (ORCID: https://orcid.org/0000-0003-3728-3182)
- José Antonio Lepe (ORCID: https://orcid.org/0000-0002-3635-4930)
- José Manuel Ortiz de la Rosa (ORCID: https://orcid.org/0000-0002-2899-7207)
- Carlos S. Casimiro‐Soriguer (ORCID: https://orcid.org/0000-0003-1774-2580)
- Carmen Soto-Gallego
- Marta Rodríguez-Rodríguez
Institutions
- Instituto de Salud Carlos III (ES)
- Fundación Progreso y Salud (ES)
- Centro de Investigación Biomédica en Red (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1093/jac/dkaf122
- Citations
- 5
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 2.96
Funders
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España
- Instituto de Salud Carlos III