Direct inhibition precedes p38 mitogen activated protein kinase-mediated uncoupling in desmosomes to reduce desmoglein 3 adhesion by pemphigus autoantibodies
The results show that autoantibody-induced direct inhibition of Dsg3 binding precedes p38 MAPK-mediated cytoskeletal uncoupling at desmosomes. Thus, the signalling function of Dsg3 in activating p38 MAPK is triggered by the loss of transinteraction, which is the primary target point for therapeutic strategies to stabilize keratinocyte adhesion in PV.
Authors
- Jens Waschke (ORCID: https://orcid.org/0000-0003-1182-5422)
- Mariya Y. Radeva (ORCID: https://orcid.org/0000-0002-9902-1682)
- Amir Sadegh Yazdi (ORCID: https://orcid.org/0000-0003-4436-3156)
- Michael Fuchs (ORCID: https://orcid.org/0000-0002-7816-3438)
- Takashi Hashimoto (ORCID: https://orcid.org/0000-0001-6779-5598)
- Thomas Schmitt (ORCID: https://orcid.org/0000-0003-3781-7236)
- Miriam Möchel
Institutions
- Universitätsklinikum Aachen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1093/bjd/ljaf142
- Citations
- 3
- Primary Topic
- Autoimmune Bullous Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.41