<i>In vivo</i> evaluation of bioactive poly(vinyl alcohol)/lecithin–clove oil nanofibers

Abstract Poly(vinyl alcohol) (PVA) was electrospun to create a bioactive nanofibrous web suitable for wound healing applications. A nanocomposite structure was developed by incorporating lecithin–clove oil into the PVA, resulting in nanogels that remain embedded in the PVA web matrix. The parameters used during the spinning process significantly affected the morphology of the nanofibers, which varied from beaded structures to smooth fibers. The web demonstrated excellent antimicrobial properties against both E. coli and S. aureus . In vivo studies using a mouse model indicated that the nanofibrous web promoted faster healing compared to the control PVA web. This promising material demonstrates great potential for use as a wound dressing. © 2025 Society of Chemical Industry.