Neutrophil extracellular traps induced by neoadjuvant chemotherapy of breast cancer promotes vascular endothelial damage
Our research underscores the capacity of TCb neoadjuvant chemotherapy in breast cancer to augment NETs formation in neutrophils through Slc11a1-mediated ROS generation, which is linked to vascular endothelial injury. Our study elucidates the potential mechanisms underlying perioperative vascular endothelial injury in breast cancer patients undergoing neoadjuvant chemotherapy, offering novel insights into perioperative therapeutic management strategies for these patients.
Authors
- Xiaobing Xiang
- Yang Yu (ORCID: https://orcid.org/0000-0003-3635-1139)
- Linghui Kong (ORCID: https://orcid.org/0000-0001-7330-3967)
- Ying Zhao (ORCID: https://orcid.org/0000-0002-1098-2832)
- Xiaoyan Zhu (ORCID: https://orcid.org/0000-0002-7173-7793)
- Pingbo Xu (ORCID: https://orcid.org/0009-0002-3974-1693)
- Yan Huang (ORCID: https://orcid.org/0000-0002-1045-4044)
- Kangjie Xie
- Song Hu (ORCID: https://orcid.org/0000-0002-6609-5730)
- Xiaochun Mao
Institutions
- Naval University of Engineering (CN)
- Zhejiang Cancer Hospital (CN)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s13058-025-02011-y
- Citations
- 3
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences